Tennessee Titans @ Miami Dolphins
In last year's meeting, former Dolphins quarterback Jimmy Garoppolo famously Floppolo'ed his way into management's doghouse during a 41-24 loss to the Titans.
Garoppolo is now resting quietly across the division in New York, while first-year signal-caller Jacoby Brissett has systematically gained the respect of his teammates by putting his ego aside.
"Last year is last year," Brissett said. "I'm not the type to dance or do any of that stuff. My job here is to simply get us the right play called at the line and take my shots when I get the chance to."
The NFL's 2nd leading scoring offense has been overshadowed (and rightly so) by the play of the the NFL's toughest defense.
Tennessee's Mike Mularkey was more than praiseworthy of Miami's style of play in his Monday press conference.
"I talked all summer about playing defense and running an exotic smash-mouth style of football," Mularkey said. "They (Miami) are the gold standard for both over there. This will be a tough matchup for us but also a great learning experience."
WHAT TO WATCH FOR: Marcus Mariota the hunted. This Miami defense loathes giving up points and yards to opposing teams. That 42-point effort from a year ago has to give them some motivation leading up to the game.
PREDICTION: Dolphins win 33-10
New York Jets @ Pittsburgh Steelers
Ben Roethlisberger, the wise veteran that he is, correctly summed up a consensus around NFL circles regarding the slow start by the New York Jets this season: Don't count on it lasting.
"I've had to watch a lot of film over the years," Roethlisberger said. "That is a great team over there - they've just had some bad breaks."
The Jets righted their 2016 ship with a statement win versus the Seattle Seahawks last week.
To continue their winning ways they will have to defeat one of the AFC's elite on the road in Pittsburgh.
"I like the challenge," Aaron Donald said. "We came into the season with people trying to crown us. We are now being talked about as down and out - we'll take the motivation if you want to slight us."
Quarterback Sam Bradford will need to erase his three-turnover first half memories against the Seahawks and build off his strong second half when he led his team back from the brink of an 0-4 start.
"There is a lot to build off of from last week," Bradford said. "We will be ready."
WHAT TO WATCH FOR: If it's Pittsburgh, then you can only talk about Antonio Brown. If he twerks once, New York can win. If he's twerking two or three times: Game Over.
PREDICTION: Steelers win 30-20
Buffalo Bills @ Los Angeles Rams
Although he's been his typically cool self with the media all week, Aaron Rodgers has to be counting down the seconds until kickoff after his poor performance last week at New England.
Rodgers will be back in his home state playing in the LA Coliseum with a chance to get his team to 4-1.
"Any time you get to play an NFL game you're excited," Rodgers said. "After last week it will be nice to get out there and play some better football."
Todd Gurley, widely projected to be drafted by the Rams two years ago, has kept the team loose all week in practice before their California adventure.
"I've been begging coach (Rex Ryan) to let us go to Disneyland or even that Hollywood sign man," Gurley said. "I've never been to LA, I can't wait to play in such a great stadium and to see the sights."
WHAT TO WATCH FOR: Despite this being a cross-country trip for the Bills, they exist as the highest of the Week 5 favorites in the NFL. Coming off a difficult loss, it would be hard to get the team to overlook any opponent. Rex Ryan should have his troops loose and ready to face the Rams.
PREDICTION: Bills win 42-21
